Effects of acetate on cerebral blood flow, systemic inflammation, and behavior in alcohol use disorder.

ABSTRACT:

Background

Alcohol use disorders (AUDs) are associated with altered regulation of physiological processes in the brain. Acetate, a metabolite of ethanol, has been implicated in several processes that are disrupted in AUDs including transcriptional regulation, metabolism, inflammation, and neurotransmission. To further understand the effects of acetate on brain function in AUDs, we investigated the effects of acetate on cerebral blood flow (CBF), systemic inflammatory cytokines, and behavior in AUD.

Methods

Sixteen participants with AUD were recruited from a nonmedical, clinically managed detoxification center. Each participant received acetate and placebo in a randomly assigned order of infusion and underwent 3T MR scanning using quantitative pseudo-continuous arterial spin

SUBMITTER: Tanabe J 

PROVIDER: S-EPMC8496991 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature