Increased Circulating CD4⁺CXCR5⁺ Cells and IgG4 Levels in Patients with Myelodysplastic Syndrome with Autoimmune Diseases.

ABSTRACT:

Objectives

Immune abnormalities play an important role in the pathogenesis and progression of myelodysplastic syndrome (MDS). Some patients with MDS have autoimmune diseases (AI). Follicular helper T (Tfh) cells help B cells produce antibodies. The role of Tfh in MDS with AI has not been studied.

Methods

We enrolled 21 patients with MDS with AI and 21 patients with MDS without AI. The proportion of peripheral blood CD4⁺CXCR5⁺ cells and the PD1 expression on CD4⁺CXCR5⁺ cells were detected by flow cytometry. Serum levels of immunoglobulin G (IgG) and IgG4 were measured. The survival and progression of MDS to acute myeloid leukemia (AML) in MDS patients with or without AI were compared.

Results

MDS with AI accounted for 19.6% o

SUBMITTER: Xiao N 

PROVIDER: S-EPMC8497158 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature