Comprehensive Analysis of m⁵C RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma.

ABSTRACT:

Background

Recent research found that N5-methylcytosine (m⁵C) was involved in the development and occurrence of numerous cancers. However, the function and mechanism of m⁵C RNA methylation regulators in clear cell renal cell carcinoma (ccRCC) remains undiscovered. This study is aimed at investigating the predictive and clinical value of these m⁵C-related genes in ccRCC.

Methods

Based on The Cancer Genome Atlas (TCGA) database, the expression patterns of twelve m⁵C regulators and matched clinicopathological characteristics were downloaded and analyzed. To reveal the relationships between the expression levels of m⁵C-related genes and the prognosis value in ccRCC, consensus clustering analysis was carried out. By univariat

SUBMITTER: Wu J 

PROVIDER: S-EPMC8497170 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature