Increased oxidative stress during exercise predicts poor prognosis in patients with acute decompensated heart failure.

ABSTRACT:

Aims

Oxidative stress plays an important role in the development and progression of heart failure (HF). Although exercise and oxidative stress are closely related, the effect of acute exercise on reactive oxygen species production and the fluctuation on prognosis are unclear.

Methods and results

We enrolled 94 patients who were hospitalized for worsening HF (mean age 68.0 ± 14.5 years old, 63.8% male). The changes in diacron-reactive oxygen metabolites (d-ROM) values, a marker of oxidative stress, before and after a cardiopulmonary exercise test were considered as Δd-ROM. The mean follow-up period was 24 ± 13 months, during which 15 patients had all-cause death or left ventricular assist system implantation. Kaplan-Meier analysis demonstrated that all-cause death or left ven

SUBMITTER: Shibata A 

PROVIDER: S-EPMC8497195 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature