Predictors of long-term outcome in heart failure with preserved ejection fraction: a follow-up from the KaRen study.

ABSTRACT:

Aims

Heart failure (HF) with preserved ejection fraction (HFpEF) has poor long-term prognosis. We assessed rates and predictors of outcome 10 years after an acute episode of HF.

Methods and results

The Karolinska-Rennes (KaRen) study enrolled HFpEF patients with acute HF, ejection fraction ≥ 45%, and N-terminal pro-brain natriuretic peptide > 300 ng/L in 2007-11. Clinical data were collected at enrolment and after 4-8 weeks including detailed echocardiography. Follow-up data were collected 10 years after study initiation, starting from 6 months after enrolment until 2018 assessed by telephone. Independent predictors of primary (all-cause mortality or HF hospitalization) and secondary (all-cause mortality) outcomes were assessed by multivariable Cox regression. Of 539 patient

SUBMITTER: Shahim A 

PROVIDER: S-EPMC8497206 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature