Ontology highlight
ABSTRACT:
SUBMITTER: Lauritsen I
PROVIDER: S-EPMC8497467 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Lauritsen Ida I Frendorf Pernille Ott PO Capucci Silvia S Heyde Sophia A H SAH Blomquist Sarah D SD Wendel Sofie S Fischer Emil C EC Sekowska Agnieszka A Danchin Antoine A Nørholm Morten H H MHH
Nature communications 20211007 1
The evolution of microorganisms often involves changes of unclear relevance, such as transient phenotypes and sequential development of multiple adaptive mutations in hotspot genes. Previously, we showed that ageing colonies of an E. coli mutant unable to produce cAMP when grown on maltose, accumulated mutations in the crp gene (encoding a global transcription factor) and in genes involved in pyrimidine metabolism such as cmk; combined mutations in both crp and cmk enabled fermentation of maltos ...[more]