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Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer.

ABSTRACT: In this article, we report the conception and the use of dialysis-based medical device for the extraction of metals. The medical device is obtained by addition in the dialysate of a functionalized chitosan that can chelate endogenous metals like iron or copper. This water-soluble functionalized chitosan is obtained after controlled reacetylation and grafting of DOTAGA. Due to the high mass of chitosan, the polymer cannot cross through the membrane and the metals are trapped in the dialysate during hemodialysis. Copper extraction has been evaluated in vitro using an hemodialysis protocol. Feasibility study has been performed on healthy sheep showing no acute toxicity througout the entire dialysis procedure and first insights of metallic extraction even on healthy animals.

SUBMITTER: Natuzzi M

PROVIDER: S-EPMC8497614 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer.

Natuzzi Marco M Grange Coralie C Gréa Thomas T Brichart Thomas T Aigle Axel A Bechet Denise D Hautefeuille Benoit B Thomas Eloise E Ayoub Jean-Yves JY Bonnet Jeanne-Marie JM Louzier Vanessa V Allaouchiche Bernard B Couturier Aymeric A Montembault Alexandra A de Oliveira Paula Nunes PN David Laurent L Lux François F Tillement Olivier O

Scientific reports 20211007 1

In this article, we report the conception and the use of dialysis-based medical device for the extraction of metals. The medical device is obtained by addition in the dialysate of a functionalized chitosan that can chelate endogenous metals like iron or copper. This water-soluble functionalized chitosan is obtained after controlled reacetylation and grafting of DOTAGA. Due to the high mass of chitosan, the polymer cannot cross through the membrane and the metals are trapped in the dialysate duri ...[more]

PMID: 34620952

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Project description:IntroductionIn this work we selected components, developed technology and studied a number of parameters of polymer nanocomposite materials, remembering that the material would have high optical and good mechanical characteristics, good sorption ability in order to ensure high value of the optical signal for a short time while maintaining the initial geometric shape. In addition, if this nanocomposite is used for medicine and biology (biocompatible or biocidal materials or the creation of a sensor based on it), the material must be non-toxic and/or biocompatible. We study the creation of polymer nanocomposites which may be applied as biocompatible materials with new functional parameters.Material and methodsA number of polymer nanocomposites based on various urethane-acrylate monomers and nanoparticles of gold, silicon oxides, zinc and/or titanium oxides are obtained, their mechanical (microhardness) properties and wettability (contact angle) are studied. The set of required, biology-related properties of these materials, such as toxicity and sorption of microorganisms are also investigated in order to prove their possible applicability.Results and discussionThe composition of the samples influences their microhardness and the value of contact angle, which means that varying with the monomer and the metallic, oxide nanoparticles composition, we could change these parameters. Besides it, the set of required, biology-related properties of these materials, such as toxicity and sorption of microorganisms were also investigated in order to prove their possible applicability. It was shown that the materials are non-toxic, the adhesion of microorganisms on their surface also could be varied by changing their composition.ConclusionThe presented polymer nanocomposites with different compositions of monomer and the presence of nanoparticles in them are prospective material for a possible bio-application as it is biocompatible, not toxic. The sorption of microorganism could be varied depending on the type of bacterias, the monomer composition, and nanoparticles.

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Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer.

Publications

Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer.

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