Painful temporomandibular joint overloading induces structural remodeling in the pericellular matrix of that joint's chondrocytes.

ABSTRACT: Mechanical stress to the temporomandibular joint (TMJ) is an important factor in cartilage degeneration, with both clinical and preclinical studies suggesting that repeated TMJ overloading could contribute to pain, inflammation, and/or structural damage in the joint. However, the relationship between pain severity and early signs of cartilage matrix microstructural dysregulation is not understood, limiting the advancement of diagnoses and treatments for temporomandibular joint-osteoarthritis (TMJ-OA). Changes in the pericellular matrix (PCM) surrounding chondrocytes may be early indicators of OA. A rat model of TMJ pain induced by repeated jaw loading (1 h/day for 7 days) was used to compare the extent of PCM modulation for different loading magnitudes with distinct pain profiles (3.5N-per

SUBMITTER: Franklin M 

PROVIDER: S-EPMC8497636 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature