TGF-Beta Receptor II Is Critical for Osteogenic Progenitor Cell Proliferation and Differentiation During Postnatal Alveolar Bone Formation.

ABSTRACT: Transforming growth factor beta (TGFβ) signaling plays an important role during osteogenesis. However, most research in this area focuses on cortical and trabecular bone, whereas alveolar bone is largely overlooked. To address the role of TGFβR2 (the key receptor for TGFβ signaling) during postnatal alveolar bone development, we conditionally deleted Tgfβr2 in early mesenchymal progenitors by crossing Gli1-Cre ^ERT2; Tgfβr2 ^flox/flox ; R26R ^tdTomato mice (named early cKO) or in osteoblasts by crossing 3.2kb Col1-Cre ^ERT2 ; Tgfβr2 ^flox/flox ; R26R ^tdTomato mice (named late cKO). Both cKO lines were indu

SUBMITTER: Xu C 

PROVIDER: S-EPMC8497707 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature