Insomnia Promotes Hepatic Steatosis in Rats Possibly by Mediating Sympathetic Overactivation.

ABSTRACT: Background: Insomnia is a widespread problem that can lead to the occurrence of other diseases and correlates closely with sympathetic nerve hyperactivation. Obesity-induced hepatic steatosis is mediated by sympathetic overactivation. However, it remains unclear whether insomnia may cause hepatic steatosis. The goal of this study was to preliminarily investigate whether insomnia caused hepatic steatosis in rats via sympathetic hyperactivation. Methods: A total of 32 Sprague-Dawley male rats were divided randomly into four groups: model, sympathetic denervation (Sd), estazolam, and control (eight rats/group). Model group received sustained sleep deprivation using the modified multiple platform method. In the Sd group, rats underwent sleep deprivation after receiving Sd

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8497715 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature