Ontology highlight
ABSTRACT:
SUBMITTER: Shiura H
PROVIDER: S-EPMC8497776 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Shiura Hirosuke H Ono Ryuichi R Tachibana Saori S Kohda Takashi T Kaneko-Ishino Tomoko T Ishino Fumitoshi F
Development (Cambridge, England) 20210924 19
The therian-specific gene paternally expressed 10 (Peg10) plays an essential role in placenta formation: Peg10 knockout mice exhibit early embryonic lethality as a result of severe placental defects. The PEG10 protein exhibits homology with long terminal repeat (LTR) retrotransposon GAG and POL proteins; therefore, we generated mice harboring a mutation in the highly conserved viral aspartic protease motif in the POL-like region of PEG10 because this motif is essential for the life cycle of LTR ...[more]