Dose-volume histogram parameters and patient-reported EPIC-Bowel domain in prostate cancer proton therapy.

ABSTRACT:

Purpose

To analyze rectal dose and changes in quality of life (QOL) measured with the Expanded Prostate and Cancer Index Composite (EPIC) bowel domain in patients being treated for prostate cancer with curative-intent proton beam therapy (PBT) within a large single-institution prospective registry.

Materials and methods

Data was collected from 243 patients with localized prostate cancer treated with PBT from 2016 to 2018. The EPIC survey was administered at baseline, end-of-treatment, 3, 6, and 12 months, then annually. Dose-volume histogram (DVH) parameters for the rectum were computed, and rectal dose was analyzed using BED (α/β = 3), EQD2Gy, and total dose. Repeated measures mixed models were implemented to determine the effect of patient, clinical, and treatment factors

SUBMITTER: Bulman GF 

PROVIDER: S-EPMC8497859 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature