The Skin Microbiome of Patients With Atopic Dermatitis Normalizes Gradually During Treatment.

ABSTRACT:

Background

Atopic dermatitis (AD) is characterized by an altered skin microbiome dominantly colonized by S. aureus. Standard treatment includes emollients, anti-inflammatory medications and antiseptics.

Objectives

To characterize changes in the skin microbiome during treatment for AD.

Methods

The skin microbiomes of children with moderate-to-severe AD and healthy children were investigated in a longitudinal prospective study. Patients with AD were randomized to receive either standard treatment with emollients and topical corticosteroids or standard treatment with the addition of dilute bleach baths (DBB) and sampled at four visits over a three-month period. At each visit, severity of AD was measured, swabs were taken from four body sites and the composition of

SUBMITTER: Khadka VD 

PROVIDER: S-EPMC8498027 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature