Splenic macrophages as the source of bacteraemia during pneumococcal pneumonia.

ABSTRACT:

Background

Severe community-acquired pneumococcal pneumonia is commonly associated with bacteraemia. Although it is assumed that the bacteraemia solely derives from pneumococci entering the blood from the lungs it is unknown if other organs are important in the pathogenesis of bacteraemia. Using three models, we tested the relevance of the spleen in pneumonia-associated bacteraemia.

Methods

We used human spleens perfused ex vivo to explore permissiveness to bacterial replication, a non-human primate model to check for splenic involvement during pneumonia and a mouse pneumonia-bacteraemia model to demonstrate that splenic involvement correlates with invasive disease.

Findings

Here we present evidence that the spleen is the reservoir of bacteraemia during pneumonia. We

SUBMITTER: Carreno D 

PROVIDER: S-EPMC8498229 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature