At the Intersection of Gut Microbiome and Stroke: A Systematic Review of the Literature.

ABSTRACT: Background: Ischemic and hemorrhagic stroke are associated with a high rate of long-term disability and death. Recent investigations focus efforts to better understand how alterations in gut microbiota composition influence clinical outcomes. A key metabolite, trimethylamine N-oxide (TMAO), is linked to multiple inflammatory, vascular, and oxidative pathways. The current biochemical underpinnings of microbial effects on stroke remain largely understudied. The goal of our study is to explore the current literature to explain the interactions between the human gut microbiome and stroke progression, recovery, and outcome. We also provide a descriptive review of TMAO. Methods: A systematic literature search of published articles between January 1, 1990, and March 22, 2020, was pe

SUBMITTER: Sharma V 

PROVIDER: S-EPMC8498333 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature