Mood disorders disrupt the functional dynamics, not spatial organization of brain resting state networks.

ABSTRACT: Spontaneous fluctuations in the blood oxygenation level dependent signal measured through resting-state functional magnetic resonance imaging have been corroborated to aggregate into multiple functional networks. Abnormal resting brain activity is observed in mood disorder patients, however with inconsistent results. How do such alterations relate to clinical symptoms; e.g., level of depression and rumination tendencies? Here we recovered spatially and temporally overlapping functional networks from 31 mood disorder patients and healthy controls during rest, by applying novel methods that identify transient changes in spontaneous brain activity. Our unique approach disentangles the dynamic engagement of resting-state networks unconstrained by the slow hemodynamic response. This time-varyin

SUBMITTER: Piguet C 

PROVIDER: S-EPMC8498469 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature