Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

ABSTRACT:

Background

A limited number of targeted therapy options exist for papillary thyroid cancer (PTC) to date. Based on genetic alterations reported by the "The Cancer Genome Atlas (TCGA)", we explored whether PTC shows alterations that may be targetable by drugs approved by the FDA for other solid cancers.

Methods

Databases of the National Cancer Institute and MyCancerGenome were screened to identify FDA-approved drugs for targeted therapy. Target genes were identified using Drugbank. Genetic alterations were classified into conferring drug sensitivity or resistance using MyCancerGenome, CiViC, TARGET, and OncoKB. Genomic data for PTC were extracted from TCGA and mined for alterations predicting drug response.

Results

A total of 129 FDA-approved drugs with 128 targetable

SUBMITTER: Hescheler DA 

PROVIDER: S-EPMC8498581 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature