Systematic Review of the Application of Perinatal Derivatives in Animal Models on Cutaneous Wound Healing.

ABSTRACT: Knowledge of the beneficial effects of perinatal derivatives (PnD) in wound healing goes back to the early 1900s when the human fetal amniotic membrane served as a biological dressing to treat burns and skin ulcerations. Since the twenty-first century, isolated cells from perinatal tissues and their secretomes have gained increasing scientific interest, as they can be obtained non-invasively, have anti-inflammatory, anti-cancer, and anti-fibrotic characteristics, and are immunologically tolerated in vivo. Many studies that apply PnD in pre-clinical cutaneous wound healing models show large variations in the choice of the animal species (e.g., large animals, rodents), the choice of diabetic or non-diabetic animals, the type of injury (full-thickness wounds, burns, radiation-induced w

SUBMITTER: Pichlsberger M 

PROVIDER: S-EPMC8498585 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature