RNA-seq profile of African American men with a clinically localized prostate cancer.

ABSTRACT:

Background

Prostate cancer in African American (AA) men has a poor prognosis. This study aimed to identify potential genetic risk factors for prostate cancer in AA men.

Methods

We used prostate cancer tissue from 61 patients who underwent radical prostatectomy. We compared somatic gene expression in Caucasian (CA) and AA men using RNA sequencing.

Results

By comparing the RNA-seq data obtained from prostate cancer tissue between AA and CA men, this study showed a significant difference in expression levels of 45 genes. Pathway analysis of 45 genes using Kyoto Encyclopedia of Genes and Genomesenrichment analysis revealed a neuroactive ligand-receptor interaction signal. In addition, the results of the Ingenuity Pathway Analysis showed pathways involved sphingosine-1-pho

SUBMITTER: Nagaya N 

PROVIDER: S-EPMC8498718 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature