Long-Term Recovery of the Adaptive Immune System in Rhesus Macaques After Total Body Irradiation.

ABSTRACT:

Purpose

Ionizing radiation causes acute damage to hematopoietic and immune cells, but the long-term immunologic consequences of irradiation are poorly understood. We therefore performed a prospective study of the delayed immune effects of radiation using a rhesus macaque model.

Methods and materials

Ten macaques received 4 Gy high-energy x-ray total body irradiation (TBI) and 6 control animals received sham irradiation. TBI caused transient lymphopenia that resolved over several weeks. Once white blood cell counts recovered, flow cytometry was used to immunophenotype the circulating adaptive immune cell populations 4, 9, and 21 months after TBI. Data were fit using a mixed-effects model to determine age-dependent, radiation-dependent, and interacting effects. T cell receptor

SUBMITTER: Macintyre AN 

PROVIDER: S-EPMC8498734 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature