Ecological and Evolutionary responses to Antibiotic Treatment in the Human Gut Microbiota.

ABSTRACT: The potential for antibiotics to affect the ecology and evolution of the human gut microbiota is well recognised and has wide-ranging implications for host health. Here, we review the findings of key studies that surveyed the human gut microbiota during antibiotic treatment. We find several broad patterns including the loss of diversity, disturbance of community composition, suppression of bacteria in the Actinobacteria phylum, amplification of bacteria in the Bacteroidetes phylum, and promotion of antibiotic resistance. Such changes to the microbiota were often, but not always, recovered following the end of treatment. However, many studies reported unique and/or contradictory results, which highlights our inability to meaningfully predict or explain the effects of antibiotic treatment on

SUBMITTER: Pennycook JH 

PROVIDER: S-EPMC8498795 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature