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Contraceptive effect of a gonadotropin-releasing hormone vaccine on a captive female African Lion (Panthera leo): a case study.

ABSTRACT: Lions (Panthera leo) breed well under captivity, so contraception has been commonly conducted for population management, leading to a demand for a less invasive and reversible contraceptive approach in lions. In this study, we examined the efficacy of a commercial gonadotropin-releasing hormone vaccine as a method of suppressing reproductive activity in a sexually matured female lion. Under behavioral restraint, the vaccine was injected twice (days 0 and 109). After the initial vaccination, ovarian activity is still observed. After the second vaccination, contraceptive effect was confirmed for 246 days until restart of estrous cycles. We confirmed only a slight swelling around the injection site after the second vaccination. This study may suggest an alternative option for a contraceptive method in lions.

SUBMITTER: Kawase K 

PROVIDER: S-EPMC8498837 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Contraceptive effect of a gonadotropin-releasing hormone vaccine on a captive female African Lion (Panthera leo): a case study.

Kawase Keisuke K   Tomiyasu Jumpei J   Ban Kazuyuki K   Ono Ryosuke R   Ando Satoshi S   Ono Aya A   Kimura Ran R   Tomisawa Kanako K   Matsui Motozumi M   Shiihara Shun-Ichi SI  

The Journal of veterinary medical science 20210719 9

Lions (Panthera leo) breed well under captivity, so contraception has been commonly conducted for population management, leading to a demand for a less invasive and reversible contraceptive approach in lions. In this study, we examined the efficacy of a commercial gonadotropin-releasing hormone vaccine as a method of suppressing reproductive activity in a sexually matured female lion. Under behavioral restraint, the vaccine was injected twice (days 0 and 109). After the initial vaccination, ovar  ...[more]

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