Transmission of extended-spectrum cephalosporin-resistant Salmonella harboring a bla_CMY-2-carrying IncA/C₂ plasmid chromosomally integrated by ISEcp1 or IS26 in layer breeding chains in Japan.

ABSTRACT: Dissemination of extended-spectrum cephalosporin (ESC)-resistant Salmonella is a public health concern in the egg production industry. ESC-resistant Salmonella often acquires the bla gene via insertion sequences (ISs). Therefore, this study aimed to assess antimicrobial resistance in Salmonella from Japanese layer breeding chains and egg processing chains, and determine the genetic profiles of IS-like elements in ESC-resistant Salmonella. Antimicrobial susceptibility testing was performed on 224 isolates from 49 facilities involving layer breeder farms, hatcheries, pullet-rearing farms, and layer farms in breeding chains along with egg processing chains. ESC-resistant Salmonella strains were whole-genome sequenced. Among them, 40 (17.9%) were resistant to at least streptomycin, tetracyclin

SUBMITTER: Shigemura H 

PROVIDER: S-EPMC8498838 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature