Switching Reactive Oxygen Species into Reactive Nitrogen Species by Photocleaved O₂ -Released Nanoplatforms Favors Hypoxic Tumor Repression.

ABSTRACT: In various reactive oxygen species (ROS)-based antitumor approaches (e.g., photodynamic therapy), increasing attentions are made to improve ROS level, but the short lifetime that is another decisive hurdle of ROS-based antitumor outcomes is not even explored yet. To address it, a photocleaved O₂ -released nanoplatform is constructed to release and switch ROS into reactive nitrogen species (RNS) for repressing hypoxic breast tumor. Systematic explorations validate that the nanoplatforms can attain continuous photocontrolled O₂ release, alleviate hypoxia, and elevate ROS level. More significantly, the entrapped PDE5 inhibitor (PDE5-i) in this nanoplatform can be enzymatically decomposed into nitric oxide that further combines with ROS to generate RNS, enabling the persi

SUBMITTER: Luo T 

PROVIDER: S-EPMC8498884 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature