MACMIC Reveals A Dual Role of CTCF in Epigenetic Regulation of Cell Identity Genes.

ABSTRACT: Numerous studies of relationship between epigenomic features have focused on their strong correlation across the genome, likely because such relationship can be easily identified by many established methods for correlation analysis. However, two features with little correlation may still colocalize at many genomic sites to implement important functions. There is no bioinformatic tool for researchers to specifically identify such feature pairs. Here, we develop a method to identify feature pairs in which two features have maximal colocalization minimal correlation (MACMIC) across the genome. By MACMIC analysis of 3306 feature pairs in 16 human cell types, we reveal a dual role of CCCTC-binding factor (CTCF) in epigenetic regulation of cell identity genes. Although super-enhancers are associ

SUBMITTER: Wang G 

PROVIDER: S-EPMC8498966 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature