Physical Frailty Phenotype Criteria and Their Synergistic Association on Cognitive Functioning.

ABSTRACT:

Background

Frailty (physical frailty phenotype [PFP]) and its criteria (slow gait, weakness, weight loss, low activity, and exhaustion) are each associated with cognitive dysfunction. The extent to which the PFP is associated with cognition beyond that expected from its component parts remains uncertain.

Method

We used the National Health and Aging Trends Study to quantify associations between PFP criteria and cognitive performance (level/change) using adjusted mixed effects models. We tested whether frailty was associated with excess cognitive vulnerability (synergistic/excess effects, Cohen's d) beyond criteria contributions by assessing interactions between each criterion and frailty.

Results

Among 7439 community-dwelling older adults (mean age = 75.2 years) follow

SUBMITTER: Chu NM 

PROVIDER: S-EPMC8499264 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature