Compositional variation of the human fecal microbiome in relation to azo-reducing activity: a pilot study.

ABSTRACT:

Background

Through an arsenal of microbial enzymes, the gut microbiota considerably contributes to human metabolic processes, affecting nutrients, drugs, and environmental poisons. Azoreductases are a predominant group of microbiota-derived enzymes involved in xenobiotic metabolism and drug activation, but little is known about how compositional changes in the gut microbiota correlate with its azo-reducing activity.

Results

To this end, we used high-throughput 16S rRNA amplicon sequencing, with Illumina MiSeq, to determine the microbial community composition of stool samples from 16 adults with different azo-reducing activity. High azo-reducing activity positively correlated with the relative abundance of phylum Firmicutes (especially genera Streptococcus and Coprococcus) bu

SUBMITTER: Zahran SA 

PROVIDER: S-EPMC8499468 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature