Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits.

ABSTRACT:

Background

A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hormones is limited, particularly in African-ancestry populations. In order to improve our understanding of the biology of cardiometabolic traits, we investigated the genetic architecture of a large panel of obesity- related cytokines and hormones among Africans with replication analyses in African Americans.

Methods

We performed genome-wide association studies (GWAS) in 4432 continental Africans, enrolled from Ghana, Kenya, and Nigeria as part of the Africa America Diabetes Mellitus (AADM) study, for 13 obesity-related cytokines and hormone

SUBMITTER: Meeks KAC 

PROVIDER: S-EPMC8499470 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature