Mechanical loading and parathyroid hormone effects and synergism in bone vary by site and modeling/remodeling regime.

ABSTRACT: Intermittent injections of parathyroid hormone (PTH) and mechanical loading are both known to effect a net increase in bone mass. Fundamentally, bone metabolism can be divided into modeling (uncoupled formation or resorption) and remodeling (subsequent formation biologically coupled to resorption in space and time). Methods to delineate the bone response between these regimes are scant but have garnered recent attention and acceptance, and will be critical tools to properly assess short- and long-term efficacy of osteoporosis treatments. To this end, we employ a time-lapse micro-computed tomography strategy to quantify and localize modeling and remodeling volumes over 4 weeks of concurrent PTH treatment and mechanical loading. Modeled and remodeled volumes are probed for differences with r

SUBMITTER: Robinson ST 

PROVIDER: S-EPMC8499476 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature