New bakuchiol dimers from Psoraleae Fructus and their inhibitory activities on nitric oxide production.

ABSTRACT:

Background

Dried fruits of Psoralea corylifolia L. (Psoraleae Fructus) is one of the most popular traditional Chinese medicine with treatment for nephritis, spermatorrhea, pollakiuria, asthma, and various inflammatory diseases. Bakuchiol is main meroterpenoid with bioactive diversity from Psoraleae Fructus. This study was designed to seek structural diverse bakuchiol derivants with anti-inflammatory activities from this plant.

Methods

Various column chromatography methods were used for isolation experiment. Structures and configurations of these compounds were determined by spectroscopic methods and single-crystal X-ray diffraction. Their inhibition on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages were evaluated by the Griess reacti

SUBMITTER: Xu Q 

PROVIDER: S-EPMC8499495 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature