Alloantigen-activated (AAA) CD4⁺ T cells reinvigorate host endogenous T cell immunity to eliminate pre-established tumors in mice.

ABSTRACT:

Background

Cancer vaccines that induce endogenous antitumor immunity represent an ideal strategy to overcome intractable cancers. However, doing this against a pre-established cancer using autologous immune cells has proven to be challenging. "Allogeneic effects" refers to the induction of an endogenous immune response upon adoptive transfer of allogeneic lymphocytes without utilizing hematopoietic stem cell transplantation. While allogeneic lymphocytes have a potent ability to activate host immunity as a cell adjuvant, novel strategies that can activate endogenous antitumor activity in cancer patients remain an unmet need. In this study, we established a new method to destroy pre-developed tumors and confer potent antitumor immunity in mice using alloantigen-activated CD4⁺

SUBMITTER: Mochizuki K 

PROVIDER: S-EPMC8499505 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature