Photothermal hydrogel platform for prevention of post-surgical tumor recurrence and improving breast reconstruction.

ABSTRACT:

Background

As one of the leading threats for health among women worldwide, breast cancer has high morbidity and mortality. Surgical resection is the major clinical intervention for primary breast tumor, nevertheless high local recurrence risk and breast tissue defect remain two main clinical dilemmas, seriously affecting survival and quality of life of patients.

Experimental

We developed a thermoresponsive and injectable hybrid hydrogel platform (IR820/Mgel) by integration of co-loaded porous microspheres (MPs) and IR820 for preventing postoperative recurrence of breast cancer via photothermal therapy and promoting subsequent breast reconstruction.

Results

Our results suggested that IR820/Mgel could quickly heated to more than 50.0 ℃ under NIR irradiation, enabling ki

SUBMITTER: Yang X 

PROVIDER: S-EPMC8499550 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature