Preimplantation genetic testing for BRCA gene mutation carriers: a cost effectiveness analysis.

ABSTRACT:

Background

Gynecologic oncologists should be aware of the option of conception through IVF/PGT-M for families with high BRCA related morbidity or mortality. Our objective was to investigate the cost-effectiveness of preimplantation genetic testing for selection and transfer of BRCA negative embryo in BRCA mutation carriers compared to natural conception.

Methods

Cost-effectiveness of two strategies, conception through IVF/PGT-M and BRCA negative embryo transfer versus natural conception with a 50% chance of BRCA positive newborn for BRCA mutation carriers was compared using a Markovian process decision analysis model. Costs of the two strategies were compared using quality adjusted life years (QALYs'). All costs were discounted at 3%. Incremental cost effectiveness ratio (IC

SUBMITTER: Michaan N 

PROVIDER: S-EPMC8499576 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature