25-hydroxycholecalciferol reverses heat induced alterations in bone quality in finisher broilers associated with effects on intestinal integrity and inflammation.

ABSTRACT:

Background

Alterations in ambient temperature have been associated with multiple detrimental effects on broilers such as intestinal barrier disruption and dysbiosis resulting in systemic inflammation. Inflammation and 25-hydroxycholecalciferol (25-OH-D₃) have shown to play a negative and positive role, respectively, in the regulation of bone mass. Hence the potential of 25-OH-D₃ in alleviating heat induced bone alterations and its mechanisms was studied.

Results

Heat stress (HS) directly induced a decrease in tibia material properties and bone mass, as demonstrated by lower mineral content, and HS caused a notable increase in intestinal permeability. Treatment with dietary 25-OH-D₃ reversed the HS-induced bone loss and barrier leak. Broilers

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8499578 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature