Low-grade peripheral inflammation affects brain pathology in the App^NL-G-Fmouse model of Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid β (Aβ) and neurofibrillary tangles. The last decade, it became increasingly clear that neuroinflammation plays a key role in both the initiation and progression of AD. Moreover, also the presence of peripheral inflammation has been extensively documented. However, it is still ambiguous whether this observed inflammation is cause or consequence of AD pathogenesis. Recently, this has been studied using amyloid precursor protein (APP) overexpression mouse models of AD. However, the findings might be confounded by APP-overexpression artifacts. Here, we investigated the effect of low-grade peripheral inflammation in the APP knock-in (App^NL-G-F) mouse model. This revealed that

SUBMITTER: Xie J 

PROVIDER: S-EPMC8499584 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature