Lean Principles to Improve Quality in High-Throughput COVID-19 Testing Using SwabSeq: A Barcoded Sequencing-Based Testing Platform.

ABSTRACT:

Objective

To describe and quantify the effect of quality control (QC) metrics to increase testing efficiency in a high-complexity, Clinical Laboratory Improvement Amendments-certified laboratory that uses amplicon-based, next generation sequencing for the clinical detection of SARS-CoV-2. To enable rapid scalability to several thousands of specimens per day without fully automated platforms, we developed internal QC methods to ensure high-accuracy testing.

Methods

We implemented procedures to increase efficiency by applying the Lean Six Sigma model into our sequencing-based COVID-19 detection.

Results

The application of the Lean Six Sigma model increased laboratory efficiency by reducing errors, allowing for a higher testing volume to be met with minimal staffing. Fur

SUBMITTER: Jones J 

PROVIDER: S-EPMC8499806 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature