Efficacy and safety of ivermectin for the treatment of COVID-19: a systematic review and meta-analysis.

ABSTRACT:

Background

Ivermectin became a popular choice for COVID-19 treatment among clinicians and the public following encouraging results from pre-print trials and in vitro studies. Early reviews recommended the use of ivermectin based largely on non-peer-reviewed evidence, which may not be robust. This systematic review and meta-analysis assessed the efficacy and safety of ivermectin for treating COVID-19 based on peer-reviewed randomized controlled trials (RCTs) and observational studies (OSs).

Methods

MEDLINE, EMBASE and PubMed were searched from 1 January 2020 to 1 September 2021 for relevant studies. Outcomes included time to viral clearance, duration of hospitalization, mortality, incidence of mechanical ventilation and incidence of adverse events. RoB2 and ROBINS-I were used

SUBMITTER: Deng J 

PROVIDER: S-EPMC8500108 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature