Periventricular and deep abnormal white matter differ in associations with cognitive performance at midlife.

ABSTRACT: Objective: Abnormal white matter (AWM) on magnetic resonance imaging is associated with cognitive performance in older adults. We explored cognitive associations with AWM during late-midlife. Method: Participants were community-dwelling men (n = 242; M = 61.90 years; range = 56-66). Linear-mixed effects regression models examined associations of total, periventricular, and deep AWM with cognitive performance, controlling for multiple comparisons. Models considering specific cognitive domains controlled for current general cognitive ability (GCA). We hypothesized that total AWM would be associated with worse processing speed, executive function, and current GCA; deep AWM would correlate with GCA and periventricular AWM would relate to specific cogni

SUBMITTER: Sanderson-Cimino M 

PROVIDER: S-EPMC8500190 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature