Genome-Wide Analysis of Cadmium-Induced, Germline Mutations in a Long-Term Daphnia pulex Mutation-Accumulation Experiment.

ABSTRACT:

Background

Germline mutations provide the raw material for all evolutionary processes and contribute to the occurrence of spontaneous human diseases and disorders. Yet despite the daily interaction of humans and other organisms with an increasing number of chemicals that are potentially mutagenic, precise measurements of chemically induced changes to the genome-wide rate and spectrum of germline mutation are lacking.

Objectives

A large-scale Daphnia pulex mutation-accumulation experiment was propagated in the presence and absence of an environmentally relevant cadmium concentration to quantify the influence of cadmium on germline mutation rates and spectra.

Results

Cadmium exposure dramatically changed the genome-wide rates and regional spectra of germline muta

SUBMITTER: Keith N 

PROVIDER: S-EPMC8500294 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature