3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects.
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ABSTRACT:
SUBMITTER: Forni M
PROVIDER: S-EPMC8500508 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
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3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects.
Forni Matilde M Thorbergsson Palmi Thor PT Thelin Jonas J Schouenborg Jens J
Science advances 20211008 41
The lack of satisfactory treatment for persistent pain profoundly impairs the quality of life for many patients. Stimulation of brainstem pain control systems can trigger powerful analgesia, but their complex network organization frequently prevents separation of analgesia from side effects. To overcome this long-standing challenge, we developed a biocompatible gelatin-embedded cluster of ultrathin microelectrodes that enables fine-tuned, high-definition three-dimensional stimulation in periaque ...[more]
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