A 6 transcription factors-associated nomogram predicts the recurrence-free survival of thyroid papillary carcinoma.

ABSTRACT:

Abstract

Various researches demonstrated that transcription factors (TFs) played a crucial role in the progression and prognosis of cancer. However, few studies indicated that TFs were independent biomarkers for the prognosis of thyroid papillary carcinoma (TPC). Our aim was to establish and validate a novel TF signature for the prediction of TPC patients' recurrence-free survival (RFS) from The Cancer Genome Atlas (TCGA) database to improve the prediction of survival in TPC patients.The genes expression data and corresponding clinical information for TPC were obtained from TCGA database. In total, 722 TFs and 545 TPC patients with eligible clinical information were determined to build a novel TF signature. All TFs were included in a univariate Cox regression model. Then, the least

SUBMITTER: Wang T 

PROVIDER: S-EPMC8500572 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature