Inertial Cavitation Behaviors Induced by Nonlinear Focused Ultrasound Pulses.

ABSTRACT: Inertial cavitation induced by pulsed high-intensity focused ultrasound (pHIFU) has previously been shown to successfully permeabilize tumor tissue and enhance chemotherapeutic drug uptake. In addition to HIFU frequency, peak rarefactional pressure ( p^- ), and pulse duration, the threshold for cavitation-induced bioeffects has recently been correlated with asymmetric distortion caused by nonlinear propagation, diffraction and formation of shocks in the focal waveform, and therefore with the transducer F -number. To connect previously observed bioeffects with bubble dynamics and their attendant physical mechanisms, the dependence of inertial cavitation behavior on shock formation was investigated in transparent agarose gel phantoms using high-speed photography and passive cavitat

SUBMITTER: Bawiec CR 

PROVIDER: S-EPMC8500614 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature