High-Frequency Oscillatory Ventilation and Ventilator-Induced Lung Injury: Size Does Matter.

ABSTRACT:

Objectives

The theoretical basis for minimizing tidal volume during high-frequency oscillatory ventilation may not be appropriate when lung tissue stretch occurs heterogeneously and/or rapidly. The objective of this study was to assess the extent to which increased ventilation heterogeneity may contribute to ventilator-induced lung injury during high-frequency oscillatory ventilation in adults compared with neonates on the basis of lung size, using a computational model of human lungs.

Design

Computational modeling study.

Setting

Research laboratory.

Subjects

High-fidelity, 3D computational models of human lungs, scaled to various sizes representative of neonates, children, and adults, with varying injury severity. All models were generated from one thoracic CT

SUBMITTER: Herrmann J 

PROVIDER: S-EPMC8500675 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature