Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus.

ABSTRACT: The subthalamic nucleus (STN) is theorized to globally suppress movement through connections with downstream basal ganglia structures. Current theories are supported by increased STN activity when subjects withhold an uninitiated action plan, but a critical test of these theories requires studying STN responses when an ongoing action is replaced with an alternative. We perform this test in subjects with Parkinson's disease using an extended reaching task where the movement trajectory changes mid-action. We show that STN activity decreases during action switches, contrary to prevalent theories. Furthermore, beta oscillations in the STN local field potential, which are associated with movement inhibition, do not show increased power or spiking entrainment during switches. We report an inhomo

SUBMITTER: London D 

PROVIDER: S-EPMC8500714 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature