Electroacupuncture Synergistically Inhibits Proinflammatory Cytokine Production and Improves Cognitive Function in Rats with Cognitive Impairment due to Hepatic Encephalopathy through p38MAPK/STAT3 and TLR4/NF-κB Signaling Pathways.

ABSTRACT:

Objective

To investigate the effect of electroacupuncture (EA) on cognitive dysfunction in rats with hepatic encephalopathy and its underlying mechanism.

Methods

Fifty Wistar rats were randomly divided into a normal group (n = 10) and model group (n = 40). Rat models of hepatic encephalopathy were established by administration of carbon tetrachloride and thioacetamide for a total of 12 weeks. At the 9th week after modeling, rats with cognitive impairment in the model group were identified by conducting the Morris water maze test, which were then randomly divided into a control group (CCl₄) and treatment groups including EA group (CCl₄ + EA), lactulose group (CCl₄ + Lac), and EA plus lactulose group (CCl₄ + CM), with 9

SUBMITTER: Huang J 

PROVIDER: S-EPMC8500758 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature