Resting-state functional MRI shows altered default-mode network functional connectivity in Duchenne muscular dystrophy patients.

ABSTRACT: Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disorder caused by absence of dystrophin protein. Dystrophin is expressed in muscle, but also in the brain. Difficulties with attention/inhibition, working memory and information processing are well described in DMD patients but their origin is poorly understood. The default mode network (DMN) is one of the networks involved in these processes. Therefore we aimed to assess DMN connectivity in DMD patients compared to matched controls, to better understand the cognitive profile in DMD. T1-weighted and resting state functional MRI scans were acquired from 33 DMD and 24 male age-matched controls at two clinical sites. Scans were analysed using FMRIB Software Library (FSL). Differences in the DMN were assessed using FSL R

SUBMITTER: Doorenweerd N 

PROVIDER: S-EPMC8500880 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature