Therapeutic strategies for systemic therapies of human papillomavirus-related oropharyngeal cancer.

ABSTRACT: Our understanding of human papillomavirus (HPV)-related oropharyngeal cancer (OPC) and its molecular basis continues to evolve and produce important insights into customized therapeutic strategies. Novel therapeutics exploiting HPV-related targets are being evaluated in the incurable setting, while the favorable prognosis of locoregionally advanced disease has stimulated investigation into de-escalation strategies. There is much opportunity for better personalization of standard therapy according to HPV status. This review discusses both current and investigational therapeutic strategies for HPV-related OPC.

SUBMITTER: Hung TKW 

PROVIDER: S-EPMC8500927 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature