Pharmacological inhibition of USP7 suppresses growth and metastasis of melanoma cells in vitro and in vivo.

ABSTRACT: Melanoma is a highly aggressive type of skin cancer. The development of diverse resistance mechanisms and severe adverse effects significantly limit the efficiency of current therapeutic approaches. Identification of the new therapeutic targets involved in the pathogenesis will benefit the development of novel therapeutic strategies. The deubiquitinase ubiquitin-specific protease-7, a potential target for cancer treatment, is deregulated in types of cancer, but its role in melanoma is still unclear. We investigated the role and the inhibitor P22077 of ubiquitin-specific protease-7 in melanoma treatment. We found that ubiquitin-specific protease-7 was overexpressed and correlated with poor prognosis in melanoma. Further, pharmacological inhibition of ubiquitin-specific protease-7 by P22077

SUBMITTER: Xiang M 

PROVIDER: S-EPMC8500953 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature