Compartment specific regulation of sleep by mushroom body requires GABA and dopaminergic signaling.

ABSTRACT: Sleep is a fundamental behavioral state important for survival and is universal in animals with sufficiently complex nervous systems. As a highly conserved neurobehavioral state, sleep has been described in species ranging from jellyfish to humans. Biogenic amines like dopamine, serotonin and norepinephrine have been shown to be critical for sleep regulation across species but the precise circuit mechanisms underlying how amines control persistence of sleep, arousal and wakefulness remain unclear. The fruit fly, Drosophila melanogaster, provides a powerful model system for the study of sleep and circuit mechanisms underlying state transitions and persistence of states to meet the organisms motivational and cognitive needs. In Drosophila, two neuropils in the central brain, the mushroom bod

SUBMITTER: Driscoll M 

PROVIDER: S-EPMC8501079 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature