Relationship of ventral striatum activation during effort discounting to clinical amotivation severity in schizophrenia.

ABSTRACT: Motivational deficits play a central role in disability due to negative symptoms of schizophrenia (SZ), but limited pathophysiological understanding impedes critically needed therapeutic development. We applied an fMRI Effort Discounting Task (EDT) that quantifies motivation using a neuroeconomic decision-making approach, capturing the degree to which effort requirements produce reductions in the subjective value (SV) of monetary reward. An analyzed sample of 21 individuals with SZ and 23 group-matched controls performed the EDT during fMRI. We hypothesized that ventral striatum (VS) as well as extended brain motivation circuitry would encode SV, integrating reward and effort costs. We also hypothesized that VS hypoactivation during EDT decisions would demonstrate a dimensional relationshi

SUBMITTER: Prettyman GE 

PROVIDER: S-EPMC8501117 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature